The elevated diet peptide related markers suggest that your husband has a high-meat diet. This is probably partly due what is discussed in number 6 above, partly due to low B6, and partly due to a slow rate of conversion of amino acids into neurotransmitters, which could be due to low tetrahydrobiopterin, resulting from the methylation cycle/folate cycle block, or due to low iron.ġ5. Several of the essential amino acids are high. since methylation is needed to make creatine, its precursor.ġ4. The low-normal creatinine would be consistent with a partial methylation cycle block. The elevated lipid peroxides shown in the oxidative stress markers is further evidence suggesting low glutathione, since selenium is in the normal range in the RBCs, though a genomic variation in the glutathione peroxidase would be another possible explanation.ġ3. This is the easiest glutathione measurement to make, but it does not reflect the level of reduced glutathione in tissue cells.
Note that the high glutathione measurement shown later in the report is a whole blood total glutathione measurement. The low-normal pyroglutamate indicates glutathione depletion in the kidneys and/or intestinal cells, which would be consistent with a partial methylation cycle block and with vitamin C deficiency. The high AKAA suggests a B6 deficiency.ġ2. Again a comprehensive stool test would be needed to identify the dysbiotic bacteria for sure.ġ1. The high-normal hydroxyphenylacetate is likely explained by bacterial dysbiosis, perhaps involving Proteus bacteria.
That would be consistent with a functional B12 deficiency and low tetrahydrofolate.ġ0. This is good evidence for a partial block in the methylation cycle. FIGlu and methylmalonate are both elevated. This is likely due to the low copper status, as found in the red blood cells, but low vitamin C could also be accounting for it.ĩ. The cause could be low B2 and/or low carnitine.Ĩ. This causes the cells to mobilize fatty acids, and they also appear to have difficulty entering the Krebs cycle, and are hence being shunted to omega oxidation. This can be accounted for by the partially blocked access of pyruvate to the Krebs cycle, described above. The ketone and fatty acids metabolites are somewhat elevated. Again, the low succinic and malic acids will also contribute to low ATP production by the mitochondria, contributing to the fatigue.ħ.
The explanation appears to be a functional deficiency in B12, given the high-normal methylmalonic acid. Since the branched-chain fatty acids are high-normal, the problem seems to be that they are not being fed into the Krebs cycle. Succinic acid is relatively low, and malic acid is below the detection limit. The latter could again be due to low magnesium or B vitamins, or to mercury toxicity.Ħ. This suggests that it is being fed by glutamate, which is also high, and that the flow from AKG to succinic acid is partially blocked. Alpha ketoglutarate is high relative to the metabolites in the Krebs cycle before and after it. The first part of his Krebs cycle is running slowly. It could also be due to mercury toxicity, in view of the high mercury level in his blood.Ĥ. This suggests a partial block in the pyruvate dehydrogenase complex, which could be due to deficiniencies in B vitamins, lipoic acid and/or magnesium. Pyruvate is not flowing into the Krebs cycle as rapidly as it should. This could be due to a low-carb diet, as one possibility.ģ. It appears that the glycolysis pathway is not running very fast. It would take a good comprehensive stool test to identify which bacteria are present in high populations.Ģ. It looks as though he has both a bacterial dysbiosis and a yeast overgrowth in his gut. Here are some comments on your husband's NutrEval results:ġ. I've also included the PDF, so I hope that works.ĭihydroxyphenylpropionic Acid (DHPPA) 6.4 (12) Low in range I find it interesting that my husband and I have almost completely different test results with similar symptoms. If anyone has any insight on his results, I would much appreciate it. He is on a restricted diet (no gluten, egg, wheat, barley, oats and more ). My husband's main symptoms are POTS and fatigue with a lot of digestive problems (constipation). Since I had one done and it showed a lot of issues, my husband decided to have one done too.
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